EFFECT OF COMPLEMENT FACTOR H ON ANTIBODY REPERTOIRE AND PROTECTION ELICITED BY MENINGOCOCCAL CAPSULAR GROUP B VACCINES CONTAINING FACTOR H BINDING PROTEIN

Effect of complement Factor H on antibody repertoire and protection elicited by meningococcal capsular group B vaccines containing Factor H binding protein

Bacteria produce surface ligands for host complement regulators Adjustable Electric Beds including Factor H (FH), which allows the bacteria to evade immunity.Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.Antibodies to FHbp can neutralize its function by inhibiting binding of FH to the bacteria and co

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Protein crystals in Adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis.

Intranuclear crystalline inclusions have been observed in the nucleus of epithelial cells infected with Adenovirus serotype 5 (Ad5) at late steps of the virus life cycle.Using immuno-electron microscopy and confocal microscopy of cells infected with various Ad5 recombinants modified in their penton base or fiber domains, we found that these inclusi

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